Overview of results from genome-wide QTL screens for stature where multipoint LOD scores over 2.0 have been reported.

Updated 25.6.2007

If you this web site in your research, please cite:
Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, et al. (2007) Combined genome scans for body stature in 6,602 European twins: Evidence for common Caucasian loci. PLoS Genet 3(6): e97. doi:10.1371/journal.pgen.0030097

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LocusPeak MarkerdeCODE cM (Kosambi)Multipoint LODPopulationNumber Phenotyped Individuals (Families)Reference
1p21D1S1631125,754,25Finnish (males-only)716 (258)Sammalisto et al 2005
1p21D1S1631125,752,25GENOA African American611 (na)Wu et al. 2003
2q11D2S113112,79a2,23Finland (Botnia)379 (58)Hirschhorn et al 2001
2q24173 cM (Marshfield)b173,5c2,33Caucasian/Australian790 (382)Ellis et al 2006
3p26D3S1297-D3S13044,94a-19,613,17United Kingdom1377 (573)Wiltshire et al. 2002
3p14D3S176679,082,31Finland702 (183)Hirschhorn et al 2001
3p21D3S130082,223,14Caucasian/Australian790 (382)Ellis et al 2006
3q23D3S1764145,532,03Multiple6752 (2508)Wu et al. 2003
3q26D3S1763168,522,06GENOA European American749 (na)Wu et al. 2003
4p16D4S4124,422,28European American1058 (26)Liu et al 2004
4q25D4S1564111,182,28Finland (Botnia)379 (58)Hirschhorn et al 2001
4q35D4S426202,692,18Finnish1531 (277)Sammalisto et al 2005
5p14-p13D5S2845-D5S147041,83a-53,872,04Dutch477 (174)Willemsen et al. 2004
5q31D5S2115136,752,14European American671 (53)Deng et al. 2002
5q31D5S816138,042,26HyperGen European American1100 (na)Wu et al. 2003
6q12D6S105381,092,66GENOA European American749 (na)Wu et al. 2003
6q12-q14D6S1053-D6S103181,09a-89,142,32Netherlands477 (174)Willemsen et al. 2004
6q25D6S2436161,273,06Netherlands962 (200)Xu et al. 2002
6q25D6S1007166,613,85Finland (Botnia)379 (58)Hirschhorn et al 2001
6q25D6S503185,242,45European American2656 (346)Geller et al 2003
7p221 cMb1a2,03Multiple8450 (3817)Perola et al. 2007
7p14D7S48454,652,05European American1816 (79)Liu et al 2004
7q21D7S669-D7S63089,39a-99,932,26United Kingdom1377 (573)Wiltshire et al. 2002
7q35D7S2195152a3,4Sweden683 (179)Hirschhorn et al 2001
7q36D7S2439-D7S1523164,44a-164,88a2,91Finland614 (247)Perola et al. 2001
7q36D7S3058175,87a2,46Multiple6752 (2508)Wu et al. 2003
8q2197cMb97a3,28Multiple8450 (3817)Perola et al. 2007
8q24D8S1100-D8S373148,81-164,472,52Finland702 (183)Hirschhorn et al 2001
9p24D9S216912,55a2,57Finnish (males-only)716 (258)Sammalisto et al 2005
9q21D9S186853,042,01Finland (Botnia)379 (58)Hirschhorn et al 2001
9p21D9S30166,992,09Netherlands962 (200)Xu et al. 2002
9q22GATA81C04M-ATA18A07M87,58a-101,644,34European American3726 (434)Liu et al 2006
9q22D9S28798,72,74European American1816 (79)Liu et al 2004
9q33D9S1682128,772,22European American1816 (79)Liu et al 2004
9q34D9S1826157,732,66European American1816 (79)Liu et al 2004
9q34D9S1818-D9S1826150,42-157,732,61Finland614 (247)Perola et al. 2001
11p15D11S2362-D11S19997,27-17,052,57Sweden683 (179)Hirschhorn et al 2001
12p13D12S3410,68a2,07Finland702 (183)Hirschhorn et al 2001
12q13D12S1090-D12S39856,52c-67,423,35Finland702 (183)Hirschhorn et al 2001
13q12D13S22116,262,76Finnish (females-only)815 (267)Sammalisto et al 2005
13q33D13S779-D13S79795,76-105,223,56Finland702 (183)Hirschhorn et al 2001
14q11GATA74E02A13,412,38Framingham Heart Study, 31-49 year-olds792Beck et al. 2003
14q11GATA74E02A13,412,45Framingham Heart Study, 61-79 year-olds792Beck et al. 2003
14q23D14S59260,53,67GENOA European American749 (na)Wu et al. 2003
14q32D14S1434100,072,01European American4692 (330)Mukhopadhyay et al 2003b
15q14D15S101238,122,61African American580 (221)Sale et al 2005
17q21D17S95874,322,69Finland (Botnia)379 (58)Hirschhorn et al 2001
18q21D18S6086,76a2,39Finnish (males-only)716 (258)Sammalisto et al 2005
18q22D18S136491,80a2,26European American4692 (330)Mukhopadhyay et al 2003b
20p1315cMb15a2,9Multiple (DZ twins)6602 (3817)Perola et al. 2007
20p1321cMb21a2,7Multiple (males)2774 (3817)Perola et al. 2007
20p12D20S66-D20S9838,23-40,76p = 0,0001Pima Indians924/226Thompson et al. 1995
20q12D20S9666,552,51Finland (Botnia)379 (58)Hirschhorn et al 2001
20q1381 cM (Marshfield)b85,0c2,21Caucasian/Australian790 (382)Ellis et al 2006
21q2123cMb23a2,25Multiple (DZ twins, males)1322 (3817)Perola et al. 2007
22q1238 cM (Marshfield)b42,03c2,03Caucasian/Australian790 (382)Ellis et al 2006
22q13D22S28250,812,85Finnish1531 (277)Sammalisto et al 2005
Xq25131cMb131a2,69Multiple (DZ twins)6602 (3817)Perola et al. 2007

a: Genetic distance interpolated using the neighbouring deCODE markers
b: Authors did not report peak marker
c: Estimated according to Nievergelt et al 2004
ns: Sequence information not available in the UCSC database


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Notes:
Deng 2002, Liu 2004 and Liu 2006 contain overlapping individuals
Sammalisto et al 2005 contains overlapping samples with Hirschhorn 2001 and Perola 2001
Mukhopadhyay et al 2003b also performed analyses modelling imprinting as well as using sex-specific maps, these are excluded from the table
Mukhopadhyay et al 2003a, Mukhopadhyay et al 2003b, Geller et al 2003 and Beck et al 2003 apparently contain overlapping individuals

Last Updated on 3 August, 2007